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Researches have demonstrated that anabolic steroids mixed with tension overload lowered MMP2 exercise (MMP2 is a gene liable for collagen manufacturing) and elevated serum values of cortisol. This decrease of IGF-1 mRNA levels induced by AAS administration may be related to the noticed decreases collagen expression when considering the possible connection between IGF-1 and collagen synthesis. During cortisol therapy, the serum ranges of genes chargeable for collagen production lower, suggesting that cortisol suppresses the synthesis of collagen manufacturing. After that, they rats had been sacrificed and the rats’ tendons and collagen were examined for gene expression. The rats have been cleverly pressured to perform resistance train, however you can’t simply inform a rat to start benching - so the researchers hooked up weights to the rats’ backs.

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